Das lumen dГјren

Das Lumen DГјren Der Spielplan für die aktuelle Woche im Das Lumen Solingen

Das Lumen Filmtheater. Fritz-Erler-Str. 21 Düren. Tickets & Infos: - 40 40 kostenlos aus dem deutschen Festnetz. Der Fall Richard Jewell. Regie: Clint Eastwood. Filmposter. FSK 12; Min. Nur kurz nachdem der Wachmann Richard Jewell als Held für die Vereitlung eines. Das Lumen Düren, Düren. Gefällt Mal. Werbefreie Leinwände, Digital 3D, D-Box Motion Seats, My Private Lumen, Lumennium Experience. Jetzt bei kinoheld Kinotickets für Das Lumen Filmtheater Düren in Düren schnell und bequem online kaufen. Das Lumen, Pl. Lumina (lateinisch lūmen ‚Licht', ‚Fenster') bezeichnet in der Anatomie, Medizin und Medizintechnik den inneren Hohlraum von Hohlorganen​.

Das Lumen, Pl. Lumina (lateinisch lūmen ‚Licht', ‚Fenster') bezeichnet in der Anatomie, Medizin und Medizintechnik den inneren Hohlraum von Hohlorganen​. SUVs higher than the SUV in the lumen plus 2 standard deviations were Drzezga, A.  V56 Dudczak, R.  P13 DГјren, C.  V98, V, TP1 Dunkelmann. Das Lumen Filmtheater. Fritz-Erler-Str. 21 Düren. Tickets & Infos: - 40 40 kostenlos aus dem deutschen Festnetz.

Das Lumen DГјren - similar documents

Schwaiger1, R. Shine a Light. Weidner1, T. Bruchertseifer3, M. Prante1, R.

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on Aug 18th, Posted by sondrafy18 on Aug 19th, Posted by MiroslavFurry on Aug 19th, Posted by georgiaam11 on Aug 19th, Posted by Vermontges on Aug 19th, Posted by NewportNewsges on Aug 19th, Posted by melodyki18 on Aug 19th, Posted by eddiezf1 on Aug 19th, Posted by patriciayo16 on Aug 19th, Posted by daphneas11 on Aug 19th, Posted by JekFeciamirak on Aug 19th, Posted by kentzl60 on Aug 19th, Posted by galeem16 on Aug 19th, Posted by leonaml11 on Aug 19th, Posted by Jamesbug on Aug 19th, Sabri3 1Nuklearmedizinische Gemeinschaftspraxis im Klinikum St.

Lindner1, M. Bisher konnte der Verlauf bei 51 dieser Patienten beobachtet werden. Die Folgeumfrage sollte u. In eckigen Klammern sind die Vergleichzahlen der letzten Erhebung gegeben.

Es wurden MPS von Becker2, I. Becker3, P. Bartenstein1, M. Hacker1, C. Griesshammer1, C. V20 The glucose metabolism in the vessel wall of patients with aneurysms of the abdominal aorta correlates with inflammatory activity M.

Essler1, C. Reeps2, S. Nekolla1, H. Eckstein2, M. It has been proposed that an inflammatory process characterized by an infiltration of the vessel wall by macrophages is the pathological basis of AAA-rupture.

The SUV in 4 sectors of the vessel wall ventral, dorsal, right lateral, left lateral of the AAA, the normal aorta and the vessel lumen was determined by an IDL-based software system that corrects the PET signal of the vessel wall for spill over effects caused by activity in the vessel lumen.

In specimens with strong macrophage infiltration significantly higher SUVs were found compared to normal aorta and the vessel lumen. The mean SUV in these segments corrected for spill over effects 3.

In aneurysms not infiltrated with macrophages the SUVs 1. SUVs higher than the SUV in the lumen plus 2 standard deviations were predictive of strong macrophage infiltration and may correlate with an impending rupture.

Hacker1, B. Huber2, C. Rischpler2, R. Fischer2, S. Nowak1, C. Zach1, M. Franz2, P. Imaging was performed 6 days after LAD-occlusion. Each mouse was anesthetized and injected with approximately MBq [99mTc]-sestamibi in the tail vein.

Left-ventricular perfusion was measured using a triple-headed single-photon emission computed tomography system, each detector head equipped with a 0.

Zoom factor was set as 2. All the images were reconstructed using 6 iterations. Dedicated software was used to generate transverse slices.

A volumetric sampling tool was applied to create polar maps of the relative distribution of activity throughout the left ventricle.

Each polar map was normalized by mean of a standardized reference ROI in the septal region, which was set as percent.

Best threshold value for identifying infarcted areas was determined after comparing perfusion defects with the histological infarct sizes in three animals 1.

Defect size was indicated as percent of left ventricular myocardium. This threshold was used for infarct size calculation. GCSF administration after myocardial infarction in mice attenuates late ischemic cardiomyopathy by enhanced arteriogenesis.

V22 Zellkinetik und Applikationseffizienz nach intrakoronarer und intramyokardialer Stammzelltransplantation im Tierexperiment M.

Schmidt1, P. Tossios2, J. Krausgrill3, T. Fischer1, K. Letztere Aufnahmen wurden nach 24h wiederholt. Es folgte ein langsamer linearer Zellverlust Phase 3.

Nach intrakoronarer Injektion ohne Balloninflation war die applizierte Zellzahl im Vergleich niedriger und es folgte eine Phase eines schnellen Zellverlustes von ca.

Im Gegensatz dazu wurde nach intramyokardialer Injektion nur eine Phase eines langsamen Zellverlustes von ca. Die Applikationseffizienz nach intrakoronarer Injektion war trotz geringerer initialer Deposition ohne Balloninflation der Applikationseffizienz mit Balloninflation nach 24h vergleichbar.

Beide Applikationswege waren der intramyokardialen Zellinjektion unterlegen. Dunzinger1, F. Hafner2, J. Brodmann2, R.

Planare Aufnahmen nach 5 bis 10 und 60 bzw Minuten wurden angefertigt. Die Befundung erfolgte durch 2 Nuklearmediziner ohne Kenntnis der Ergebnisse der anderen bildgebenden Verfahren.

Positive szintigraphische Ergebnisse waren bis zu 17 Tage nach Beginn der Symptome nachzuweisen. Bei einem Patienten mit positiver Szintigraphie war das D-Dimer negativ.

Schuchardt1, S. Senftleben1, R. In previous studies, large standard deviations SD for the important dosimetric parameters uptake and mean absorbed dose were found.

The aim of this ongoing study is to determine the intra- and inter-patient variability of these parameters. Eight patients were treated in 3 cycles with activities of 4.

The high inter-patient variability of normal organs is mainly due to the different disease status of the patients large heterogeneity in tumor burden.

Different receptor densities among patients and tumors result in a high variability of the dose to metastases.

The results also show a large intra-individual variability which can be contributed to previous treatments effective radiopeptide therapy. However, the reasons for the large standard deviations have to be further evaluated in more detail.

We conclude that individual patient dosimetry needs to be performed for each therapy course due to the large intra-patient variability.

Ezziddin1, M. Damm1, M. Eskangi1, H. Ahmadzadehfar1, S. Guhlke1, J. Bucerius1, K. Biermann1, H. Palmedo1, H. Biersack1, K. Es zeigte sich ein klarer Trend zur Abnahme der Tumordosis bei konsekutiven Therapiezyklen.

Die Nierendosis betrug 1. Gotthardt1, A. Eek1, P. Laverman1, F. Corstens1, W. Oyen1, O. Boerman1 1Universitair Medisch Centrum St. Diese Behandlung kann jedoch mit Nebenwirkungen einhergehen.

Es wurden 4 Wistarratten per Gruppe eingesetzt. Die Verteilung in der Niere wurde durch Autoradiographie bestimmt. Kotzerke1, R.

Freudenberg1, G. Wunderlich1, T. Eine posttherapeutische Dosimetrie erlaubt einen Vergleich von Nierendosis und Entwicklung der Nierenfunktion.

Kreatinin i. Die Nierenexposition einzelner Fraktionen wurde addiert. Weitere Verlaufskontrollen sind erforderlich, da sich eine Strahlennephropathie auch schleichend im Verlauf von Jahren nach Therapie entwickeln kann.

Neininger1, H. Dittmann1, M. Klein1, M. Elahi1, R. Alle Werte lagen aber noch im altersentsprechenden Referenzbereich.

Bei einzelnen Patienten kommt es allerdings zu einer statistisch signifikanten Reduktion der Nierenfunktion. Im weiteren Verlauf wurde tendenziell eine weitere Abnahme festgestellt, die bei geringer Fallzahl keine statistische Signifikanz erreichte.

Eine manifeste Niereninsuffizienz wurde bei keinem Patienten beobachtet. Prasad1, C. Schuchardt1, C. Zachert1, M. Kupfer1, J.

Mundschenk1, R. After first line treatment, therapeutic options for locally recurrent or metastasizing tumors include repeated surgery, whenever possible.

While differentiated thyroid cancer shows high expression of sstr 1, 3, 4 and 5, MTC expresses preferentially subtypes sstr 2 and sstr 5.

Only patients with high SMS-R-expression were selected for therapy. Out of patients, mostly with gastroenteropancreatic neuroendocrine tumors, 4 patients had follicular thyroid carcinoma FTC , 5 patients had MTC, 1 patient had a mixed form FTC and MTC and 2 patients had oncocytic carcinoma.

All patients had undergone total thyroidectomy, multiple radioiodine therapies DTC , repeated surgeries, external beam radiation therapy, chemotherapy etc.

PRRT was performed according to our standard procedure, including kidney protection with amino acid infusions. The patients received cumulative doses of 3.

Post-therapeutic dosimetry was performed. In FTC, 1 out of 4 patients showed disease stabilization, the other patients had progressive disease.

Both of the patients with the oncocytic variant had SD at current follow-up. The patient with a mixed form showed no response to PRRT and remained progressive.

These results are similar to those reported by other groups. V30 Therapiekontrolle einer Radiopeptidtherapie Y bzw. Aschoff2, H.

Bitzer3, M. Klein1, S. Eschmann4, M. Pfannenberg2, R. Ergebnisse: Die konventionelle Diagnostik s. Baum1, V.

Zachert1, R. Wortmann1, M. Hommann2, D. Lu-TATE was predominantly used for small metastases or in patients with impaired renal or hematological function.

For kidney protection, 1. End stage renal insuffiency was not observed in any of the patients with normal kidney function before PRRT.

Objective tumor responses including significant improvement of clinical symptoms were seen in Reimold1, I.

Liepelt2, W. Maetzler2, G. Reischl3, D. Berg2, R. Bei PDD, z. Die FDG-Verteilung 40min p. Die ersten 7 PD Pat. Diese Maske wurde auf alle Patienten und KO angewendet um einen individ.

Cortex, sowie Teile des front.. In einer mult. Einfluss des MMSE partial corr. Teipel2, C. Zach1, H. Hampel2, P. Bartenstein1, K. Visuo-spatial impairment is of high clinical relevance as it limits the ability of patients to live in the community.

Several PET studies investigated the relationship between the regional pattern of cortical metabolism and the profile of cognitive impairment in AD patients.

Patients with predominant language impairment showed left predominant cortical hypometabolism, whereas predominant right hemispheric hypometabolism was associated with impairment of visuoconstructive abilities.

Aim of this study was to examine the cortical functional representation of visuo-spatial deficits in AD-patients correlating FFDG-PET with neuropsychological domains for the assessment of visual-constructional functioning.

Emission scans were aquired 30 min. In contrast, performance in the analytically more complex RO test also included areas along the ventral visual stream involved in object recognition, and right prefrontal lobe areas involved in sustaining attention and working memory.

Thus, the combination of resting state FDG-PET with a detailed analysis of cognitive profiles in AD is a powerful tool to study the cortical representation of specific cognitive domains in the human brain.

Kendziorra1, P. Meyer1, H. Barthel1, S. Hesse1, A. Schildan1, M. Patt1, A. Seese1, G. Becker1, D. Sorger1, H. Wolf2, H. Gertz2, U.

Hegerl2, O. Entsprechende in-vivo-Daten liegen bisher jedoch nicht vor. Mittels Logan-Plot und einer um radioaktiven Zerfall, Plasmaproteinbindung und Metabolite korrigierten individuellen, arteriellen Input-Funktion wurde das Distributionsvolumen DV errechnet.

Brockmann1, A. Zobel2, K. Biermann1, A. Joe1, J. Bucerius1, L. Scheef3, H. Biersack1, W. Maier2, H. Geplant ist, genetische Daten des Patientenkollektivs in die Analyse mit einzubeziehen.

Reimold1, A. Knobel2, M. Rapp2, C. Solbach3, G. Reischl3, A. Batra4, M. Smolka5, A. Zimmer5, H. Machulla3, R. Bares1, A. V37 Effects of behavioral therapy or pharmacotherapy on scaled brain glucose metabolism in subjects with obsessive-compulsive disorder as assessed by brain FDG PET I.

Apostolova1, S. Block1, R. Buchert1, I. Hand2, M. Clausen1, J. Concomitant major depressive disorder MDD was present in 1 subject only.

Post-to-pre-treatment change of scaled LMRGlc SLMRGlc was assessed separately in therapy responders and non-responders within the following volumes of interest selected a priori: left and right head of caudate nucleus, and left and right orbitofrontal cortex.

Whether this effect is primarily related to the improvement of OCD symptoms or it is secondary to concomitant improvement of depression symptoms requires further clarification.

As long as this question is open, severity of depression symptoms should be considered an important covariate in the evaluation of the effects of therapy on the glucose metabolism in subjects with OCD, not only in OCD subjects with concomitant MDD but also in subjects who do not meet the criteria for MDD.

Hesse1, K. Stengler2, R. Regenthal3, G. Becker1, M. Patt1, H. Assmann2, H. Roth4, D. Lobsien4, H.

Barthel1, W. Heinke5, U. Neurosci Biobehav Rev ; 2 Ichise et al. Luthardt1, S. Hesse1, O. Ballaschke2, O. Zimmermanns1, N. Brenner2, H.

Royer2, K. Servan2, T. Fischer1, M. Dietlein1, M. Matzkies3, J. Hescheler3, H. Schicha1, K. Die undifferenzierten Zellen wurden 10 Tage nach Einbringen der Zellen auf die Feederzellen durch Ausschneiden geerntet.

Fischer1, W. Eschner1, B. Zimmermanns1, H. In Vorarbeiten konnte gezeigt werden, dass in Kombination mit Auger-Elektronen emittierenden Radionukliden die markierte Verbindung ein hohes Potenzial zur nebenwirkungsarmen Behandlung ER-positiver Tumoren und insbesondere ihrer Metastasen bietet.

Die mikrodosimetrischen Berechnungen wurden mit Hilfe der von Goddu et al. Nerlich1, R. Lorenz1, V.

Meineke2, C. Reiners1, H. Ein eindeutiger Zusammenhang zwischen der Dosis bzw. Um den Zusammenhang zwischen Dosis bzw.

PNAS Rad Res. Seidl1, M. Port2, A. Morgenstern3, M. Schwaiger1, R. Senekowitsch-Schmidtke1, M. Je ca.

Insgesamt 8 Gene waren durchweg hoch- und 12 Gene durchweg herunterreguliert. Sudbrock1, F. Boldt1, C.

Kobe1, H. Insbesondere verdienen PET Untersuchungen mit F besondere Beachtung: Handelt es sich um einen Dauerarbeitsplatz ohne bauliche Abschirmung, so ist die Einhaltung eines Abstands zum Patienten von mindestens sechs bis sieben Metern zum Patienten zu empfehlen.

Benatar NA et al. Greaves CD et al. Empfehlung der Strahlenschutzkommission Barth1, H. Wengenmair2, G.

Leissner3, J. Scuik4, T. Nikula5, O. Rimpler1, S. Senftleben2, I. Barth1, R. Wortmann2, R. Eckardt1, G. Lottes1, O. In einem Beispiel in o.

Truong1, K. Zaplatnikov1, C. Happel1, M. Middendorp1, W. Plastowez1, I. Selkinski1, B. Sauter1, W. Kranert1, J. Diener1, F.

Flow - min. Kurve - min. Die statistische Auswertung erfolgte mittels Spearman-Korrelation. Groth1, S. Dunkelmann1, B. Rohde1, A. Hauschild1, C.

Infolge dessen bleibt der Tcm-Pertechnetat-Uptake hoch, der IStundenUptake ist dagegen niedrig bis fehlend. Nativ besteht keine TSH-Suppression.

V50 Radioiodtherapie der funktionellen Autonomie: Welche Zieldosis ist erforderlich? Dittmann1, S. Rieger1, S. Eschmann1, J. Die weltweit angewendeten Konzepte zur Therapieplanung sind ebenso wie auch die angestrebten Zieldosen unterschiedlich.

Ziel dieser retrospektiven Untersuchung war die Korrelation zwischen erreichter Herddosis und Therapieerfolg sowie die Analyse weiterer prognostisch relevanter Faktoren.

Bachmann1, M. Schmidt1, C. Eine radiogene immunogene Hyperthyreose bzw. Immunhyperthyreose M. Kobe1, I.

Weber1, W. Eschner1, F. Sudbrock1, J. Bachmann1, F. Boldt1, I. Rahlff1, M. Schmidt1, M. Die im Radioiodtest berechnete Zieldosis betrug Gy.

Die thyreostatische Medikation wurde retrospektiv mit dem Therapieergebnis verglichen. V53 M. Hautzel1, K. Kley1, A. Heinzel1, R.

Grandt1, A. Bachofner1, H. Basedow Pat. Die persistierende Hyperthyreose der Non-Responder wurde bei 22 Pat. Basedow Strumen Verkleinerungen zu erreichen, die denen bei M.

Rahlff1, C. Kobe1, W. Boldt1, M. Basedow eine Halbwertszeit von 4,2 d angegeben. Eine individuelle Dosimetrie ist in Deutschland auch gesetzlich vorgeschrieben 1.

Richtlinie nach der StrlSchV. Dunkelmann1, H. Kurth1, P. Groth1, C. Basedow wurde der diagnostische IUptake an einer Sonde nach 4, 6, 8, 10, 22, 24, 26, 32, 46, und 48 Std.

Uptake, der Zeitpunkt des max. Uptakes und die eff. Halbwertszeit HWZ von Radioiod berechnet.

Hierzu wurde ein einfaches Zwei-Kompartimentmodell verwendet, welches die intrathyroidale Radioiodkinetik mittels zweier Exponential-Funktionen sehr exakt beschreibt.

Der mittlere max. Die diagnostische eff. Das mittlere Produkt aus kumulativen max. Bei einer VDZ von 2,4 Std.

Manook1, G. Henriksen1, S. Platzer2, A. Weber1, B. Yousefi1, M. Settles3, M. Schwaiger1, H. Wester1, A. Nach i. Buchholz1, B.

Alessandri2, M. Behzad2, H. Baechli3, A. Heimann2, O. Kempski2, M. In Grp. Bei den Paraffintieren ergab sich im Vergleich ipsi- zu kontralateral kein signifikanter Unterschied im Glukosemetabolismus.

Nikolaus1, M. Beu1, R. Larisch2, A. Wirrwar1, H. Dabei entsprachen x und y den freien bzw. BP betrug 2,6. Beu1, C. Antke1, K.

Der beobachtete Deckeneffekt wurde zuvor beschrieben 1 und ist u. Egberts2, R. Buchert3, K. Peldschuss4, H. Kalthoff2, E. Henze1, W.

FCholin zeigte dagegen bei allen Zellreihen so gut wie keine Verstoffwechselung. In unserem Modell nehmen wir an, dass auch hier ein hoher Uptake zu verzeichnen ist aufgrund einer Vielzahl von TK1.

Reuter2, G. Gabriels3, O. Schober1, E. Schlatter2, M. Wirrwar1, D. Buchholz1, O. Gottschalk2, B. Ostendorf3, F.

Schwaiger2, S. Schramm4, H. Michaelis5, M. Sie wurden, bevor sie die Studien begannen, mittels eines makroskopischen Scores eingestuft.

Nach Injektion von Hermann1, M. Kuhlmann1, A. Faust1, K. Kopka1, M. Aufgrund der unterschiedlichen Halbwertzeiten der verwendeten Isotope lassen sich die beiden Tracerinformationen aus dem Listmode-Datensatz separieren.

Herth1, F. Debus2, M. Piel1, M. Palner3, P. Riss1, G. Knudsen3, H. A radioligand competition binding assay was carried out with GF cells, a clonal cell line expressing high amounts of the 5-HT2A receptor, in test tubes containing Faltanserin and seven different concentrations of test compound in a total of 1 mL assay buffer.

Ketanserin was used to determine non-specific binding. To optimize radiochemical yields of the ligand, different reaction parameters were systematically examined.

First autoradiographic and PET images showed excellent and specific binding. Deuther-Conrad1, F. Wegner2, M. Scheunemann1, S. Diekers3, P.

Brust1, A. Besides insomnia, impaired GABAergic neurotransmission has been implicated in various neuropsychiatric diseases. The radiosynthesis of selected compounds was achieved by n.

F nucleophilic substitution. In vitro autoradiography of the F labelled pyrazolopyrimidines was performed on rat and pig brain slices in comparison to Hflunitrazepam.

The in vivo properties of two F labelled derivatives were investigated in NMRI mice by analysing brain uptake, organ distribution, ex vivo autoradiography, and metabolic stability.

The autoradiography of the Flabelled compounds resembles the benzodiazepine binding in rat and porcine brain in vitro. However, the intravenous application of the radiotracers revealed a significant biotransformation and the presence of radiometabolites in the mice brain.

However, the in vivo applicability of the Flabelled indiplon derivatives suffers from an extensive metabolism. The future work will focus on structural modifications expected to improve the in vivo properties of indiplon derived radiotracers.

Prante1, R. Tietze1, C. Hocke1, S. Gmeiner2, T. We here present the discovery of a promising inverse agonist D4R ligand for PET derived from these lead compounds.

Mitogenesis experiments were performed with a CHOA cell line using quinpirole treatment as a reference. Sprague-Dawley rats were used for biodistributional studies.

LogP was 2. In-vitro rat brain autoradiography demonstrated specific binding in the gyrus dentate of the hippocampus, hypothalamus, medial habenular nucleus, central medial thalamic nucleus, septum and cortex, that was inhibited by FAUC and eticlopride.

Biodistributional studies showed highest uptake in the liver 4. Regional brain uptake was 0. Ex-vivo autoradiography exellently confirmed the in-vitro binding pattern.

Hummerich1, P. Schloss1, F. We were interested in the effect of conformationally restricted N-substituents onto DAT selectivity, affinity and pharmacokinetic properties.

Methods: - -Anhydroecgonin methyl ester was prepared from commercially available cocaine hydrochloride[4]. Addition of an appropriate Grignard reagent[5] and subsequent N-demethylation afforded four p-substituted phenyltropanes a-d.

Results: A promising set of novel tropane-derivatives table 1 has been prepared along with some established selective DAT-radioligands as references.

These promising candidates were labelled via direct 18F-fluorination and characterised in vitro and in vivo.

Compared to LBT, affinity and selectivity both have been improved. All new compounds are well suited for direct radio fluorination.

In addition, all reference compounds provide at least one site for convenient 3H or 14C labelling, which may facilitate in vitro binding studies as well as autoradiographic evaluation.

Steiniger1, R. Bergmann1, J. Pietzsch1, F. Depression [1]. Dabei sollten besonders verschiedene GR-bindende Chromenderivate als neueuartige nicht-steroidale GR-Liganden mit 11C markiert und radiopharmakologisch charakteri-siert werden.

Die radio-pharmakologische Charakterisierung der hergestellten Verbindungen umfasste Bioverteilungs-untersuchungen, Autoradiographie und dynamische Kleintier-PET-Untersuchungen mit normalen Wistar-Ratten.

Bioverteilungsstudien zeigten Hirnanreicherungen von bis zu 1. De Kloet et al. Reischl1, F. Maier2, F. Hammerschmidt3, A. Woschek3, W.

Ehrlichmann1, D. Lamparter1, M. Kneilling4, B. Pichler2, H. Alle 3 Tracer zeigten eine deutliche Elimination aus dem Gewebe innerhalb 3 h.

Cancer Res. Imaging , 34, Maier1, G. Reischl2, M. Kneilling3, F. Cay1, D. Bukala1, M. Judenhofer1, H. Machulla2, B. Static small animal PET scans were performed 1, 2 and 3 hours post intravenous tracer injection.

Anaesthesia was performed with 1. After the PET scans, tumors were dissected and analyzed by autoradiography and immunofluorescent detection of hypoxia with pimonidazole.

Normalized PET images were analyzed by using defined volumes of interest. Immunohistochemistry with pimonidazole confirmed these results. Interestingly, the different breathing protocols revealed, that highest increase in [18F] FAZA uptake can be achieved when oxygen is supplied after tracer injection; pure oxygen supply before tracer injection does not significantly change the tumor uptake.

Patt2, A. Schildan2, H. Franke3, J. Boltze4, D. Wagner4, P. Illes3, F. Emmrich4, O. Sabri2, H. Raumluft bis zu 2h ausgesetzt wurden.

Hier wurde 15, 30, 60 und min p. Fischer1, E. Hellrung1, B. Zimmermanns1, M. Bei Tcm-Pertechnetat, I und IIodid zeigen nur die nicht-resistenten Zellen einen Apoptoseanstieg, die multidrug-resistenten Zellen reagieren dagegen nicht.

Wird jedoch I an Deoxyuridin gebunden angeboten, so reagieren auch die resistenten Zellen mit dem gleichen Anstieg apoptotischer Zellen wie die sensitiven MCFZellen.

Schweizer1, I. Cenova1, A. Sattler1, A. Seese1, H. Barthel1, M. Schildan1, J. Petzold1, G. Holl2, S. Lindemann3, E. Hammerstein4, H.

Gertz4, U. Hegerl4, O. Jedes Frame bestand aus Bettpositionen einer Dauer von je 1 min. Hahner2, S. Johanssen2, M.

Fassnacht2, B. Allolio2, C. Reiners1, A. Schirbel1, M. Johanssen2, H. Die ersten klinischen Ergebnisse sind vielversprechend.

Ezziddin1, T. Logvinski1, H. Ahmadzadehfar1, K. Biermann1, J. Bucerius1, G.

Kurtz1, D. Liepe1, W. Sneak-Preview Laserprojektion Sa. Weber1, W. Sneak Preview. Laura bro Volumina wurden miteinander verglichen. Mundschenk1, R.

Pohle2, O. Schober3, W. Sahlmann1, T. Liersch2, M. Niessner2, U. Siefker1, A. Hamann1, T. Lorf2, B.

Ghadimi2, H. Becker2, D. Goldenberg3, J. Ein Patient mit kleinstherdiger pulmonaler Metastasierung wurde falsch negativ gewertet.

Weber1, A. Beer1, B. Wolf2, M. Schwaiger1, S. The NPV was PET-negative patients, who were assessed as partial response by CT, had a prognosis similar to those in complete remission.

Bei Patienten wurde keine vermehrte, bei eine schwache und bei 71 eine starke rektale FDG-Anreicherung detektiert.

Diese war bei Patienten fokal, bei 72 Patienten langstreckig und bei 43 Patienten diffus. Bei Patienten wurde keine vermehrte, bei eine schwache und bei eine starke anale FDG-Anreicherung detektiert.

Diese war bei Patienten fokal, bei Patienten langstreckig und bei 31 Patienten diffus. Bei keinem dieser Patienten wurde im weiteren Verlauf eine maligne Raumforderung des Rektums oder des Analsphinkters nachgewiesen.

Seidensticker1, A. Pethe1, M. Seemann1, O. Denecke2, H. Amthauer2, M. Pech1, J. Alle Patienten befanden sich in einem Stadium der ausgereizten chirurgischen und onkologischen Therapieoptionen und wiesen eine progrediente Situation der Lebermetastasierung auf.

Hamami1, G. Antoch2, P. Hilgard3, J. Ertle3, S. Seemann1, G. Ulrich1, R. Pech1, A. Pethe1, H. Amthauer2, L.

Geworski2, J. Dabei wurde das 70keV-Fenster zur Bilddatenrekonstruktion verwendet. Hamami1, D.

Wedeleit1, W. Sonnenschein1, A. In der Praxis geht jedoch die Tumorperfusion nicht in die dosimetrischen Berechnungen ein 1,2. Ahmadzadehfar1, H.

Brockmann1, S. Ezziddin1, A. Sabet1, K. Biermann1, K. Wilhelm2, H. Biersack1, H. Due to the fact that Y is a pure beta emitter, the only way to visualize the accumulation of microspheres in the liver is to obtain low-resolution Bremsstrahlung scans.

The aim of this study is to evaluate the role of post therapeutic Bremsstrahlung scans in confirming the distribution of microspheres in liver.

Patients were treated with SIRT from December to September after a previous Tcm-MAA scan to determine the degree of shunting from the liver to the lung or gastrointestinal tract.

The application of treatment to both liver lobes was performed in 14 and 5 patients in one and two therapy sessions respectively. In the remaining patients, the SIRT was necessary in one liver lobe only.

Whole body Bremsstrahlung scans were performed in all patients h after therapy. These scans were compared to MAA-scans to confirm the distribution of the therapeutic microspheres.

In 17 scans In just only one patient 2. A discrepancy between MAA and Bremsstrahlung scan, even if rarely, necessitates implementation of the Bremsstrahlung scan due to its clinical relevance.

Blodow1, G. Hoffmann2, T. Waggershauser2, K. Lediglich in einem Fall erforderten ausgedehnte Ulzerationen eine chirurgische Intervention.

Zuderman1, K. Liepe1, W. Luboldt1, A. Andreeff1, K. Zoephel1, J. Hohdorf1, M. Gresens2, T. Lincke3, S. Hesse3, W.

Seidel4, C. Melzer2, O. Sabri3 1Nuklearmedizinische Gemeinschaftspraxis im Klinikum St. Lindner1, M. Bisher konnte der Verlauf bei 51 dieser Patienten beobachtet werden.

Die Folgeumfrage sollte u. In eckigen Klammern sind die Vergleichzahlen der letzten Erhebung gegeben. Es wurden MPS von Becker2, I.

Becker3, P. Bartenstein1, M. Hacker1, C. Griesshammer1, C. V20 The glucose metabolism in the vessel wall of patients with aneurysms of the abdominal aorta correlates with inflammatory activity M.

Essler1, C. Reeps2, S. Nekolla1, H. Eckstein2, M. It has been proposed that an inflammatory process characterized by an infiltration of the vessel wall by macrophages is the pathological basis of AAA-rupture.

The SUV in 4 sectors of the vessel wall ventral, dorsal, right lateral, left lateral of the AAA, the normal aorta and the vessel lumen was determined by an IDL-based software system that corrects the PET signal of the vessel wall for spill over effects caused by activity in the vessel lumen.

In specimens with strong macrophage infiltration significantly higher SUVs were found compared to normal aorta and the vessel lumen.

The mean SUV in these segments corrected for spill over effects 3. In aneurysms not infiltrated with macrophages the SUVs 1.

SUVs higher than the SUV in the lumen plus 2 standard deviations were predictive of strong macrophage infiltration and may correlate with an impending rupture.

Hacker1, B. Huber2, C. Rischpler2, R. Fischer2, S. Nowak1, C. Zach1, M. Franz2, P. Imaging was performed 6 days after LAD-occlusion.

Each mouse was anesthetized and injected with approximately MBq [99mTc]-sestamibi in the tail vein. Left-ventricular perfusion was measured using a triple-headed single-photon emission computed tomography system, each detector head equipped with a 0.

Zoom factor was set as 2. All the images were reconstructed using 6 iterations. Dedicated software was used to generate transverse slices.

A volumetric sampling tool was applied to create polar maps of the relative distribution of activity throughout the left ventricle.

Each polar map was normalized by mean of a standardized reference ROI in the septal region, which was set as percent.

Best threshold value for identifying infarcted areas was determined after comparing perfusion defects with the histological infarct sizes in three animals 1.

Defect size was indicated as percent of left ventricular myocardium. This threshold was used for infarct size calculation.

GCSF administration after myocardial infarction in mice attenuates late ischemic cardiomyopathy by enhanced arteriogenesis.

V22 Zellkinetik und Applikationseffizienz nach intrakoronarer und intramyokardialer Stammzelltransplantation im Tierexperiment M.

Schmidt1, P. Tossios2, J. Krausgrill3, T. Fischer1, K. Letztere Aufnahmen wurden nach 24h wiederholt.

Es folgte ein langsamer linearer Zellverlust Phase 3. Nach intrakoronarer Injektion ohne Balloninflation war die applizierte Zellzahl im Vergleich niedriger und es folgte eine Phase eines schnellen Zellverlustes von ca.

Im Gegensatz dazu wurde nach intramyokardialer Injektion nur eine Phase eines langsamen Zellverlustes von ca. Die Applikationseffizienz nach intrakoronarer Injektion war trotz geringerer initialer Deposition ohne Balloninflation der Applikationseffizienz mit Balloninflation nach 24h vergleichbar.

Beide Applikationswege waren der intramyokardialen Zellinjektion unterlegen. Dunzinger1, F. Hafner2, J. Brodmann2, R. Planare Aufnahmen nach 5 bis 10 und 60 bzw Minuten wurden angefertigt.

Die Befundung erfolgte durch 2 Nuklearmediziner ohne Kenntnis der Ergebnisse der anderen bildgebenden Verfahren.

Positive szintigraphische Ergebnisse waren bis zu 17 Tage nach Beginn der Symptome nachzuweisen. Bei einem Patienten mit positiver Szintigraphie war das D-Dimer negativ.

Schuchardt1, S. Senftleben1, R. In previous studies, large standard deviations SD for the important dosimetric parameters uptake and mean absorbed dose were found.

The aim of this ongoing study is to determine the intra- and inter-patient variability of these parameters.

Eight patients were treated in 3 cycles with activities of 4. The high inter-patient variability of normal organs is mainly due to the different disease status of the patients large heterogeneity in tumor burden.

Different receptor densities among patients and tumors result in a high variability of the dose to metastases.

The results also show a large intra-individual variability which can be contributed to previous treatments effective radiopeptide therapy.

However, the reasons for the large standard deviations have to be further evaluated in more detail. We conclude that individual patient dosimetry needs to be performed for each therapy course due to the large intra-patient variability.

Ezziddin1, M. Damm1, M. Eskangi1, H. Ahmadzadehfar1, S. Guhlke1, J. Bucerius1, K. Biermann1, H. Palmedo1, H. Biersack1, K. Es zeigte sich ein klarer Trend zur Abnahme der Tumordosis bei konsekutiven Therapiezyklen.

Die Nierendosis betrug 1. Gotthardt1, A. Eek1, P. Laverman1, F. Corstens1, W. Oyen1, O. Boerman1 1Universitair Medisch Centrum St. Diese Behandlung kann jedoch mit Nebenwirkungen einhergehen.

Es wurden 4 Wistarratten per Gruppe eingesetzt. Die Verteilung in der Niere wurde durch Autoradiographie bestimmt.

Kotzerke1, R. Freudenberg1, G. Wunderlich1, T. Eine posttherapeutische Dosimetrie erlaubt einen Vergleich von Nierendosis und Entwicklung der Nierenfunktion.

Kreatinin i. Die Nierenexposition einzelner Fraktionen wurde addiert. Weitere Verlaufskontrollen sind erforderlich, da sich eine Strahlennephropathie auch schleichend im Verlauf von Jahren nach Therapie entwickeln kann.

Neininger1, H. Dittmann1, M. Klein1, M. Elahi1, R. Alle Werte lagen aber noch im altersentsprechenden Referenzbereich.

Bei einzelnen Patienten kommt es allerdings zu einer statistisch signifikanten Reduktion der Nierenfunktion. Im weiteren Verlauf wurde tendenziell eine weitere Abnahme festgestellt, die bei geringer Fallzahl keine statistische Signifikanz erreichte.

Eine manifeste Niereninsuffizienz wurde bei keinem Patienten beobachtet. Prasad1, C. Schuchardt1, C. Zachert1, M. Kupfer1, J.

Mundschenk1, R. After first line treatment, therapeutic options for locally recurrent or metastasizing tumors include repeated surgery, whenever possible.

While differentiated thyroid cancer shows high expression of sstr 1, 3, 4 and 5, MTC expresses preferentially subtypes sstr 2 and sstr 5.

Only patients with high SMS-R-expression were selected for therapy. Out of patients, mostly with gastroenteropancreatic neuroendocrine tumors, 4 patients had follicular thyroid carcinoma FTC , 5 patients had MTC, 1 patient had a mixed form FTC and MTC and 2 patients had oncocytic carcinoma.

All patients had undergone total thyroidectomy, multiple radioiodine therapies DTC , repeated surgeries, external beam radiation therapy, chemotherapy etc.

PRRT was performed according to our standard procedure, including kidney protection with amino acid infusions.

The patients received cumulative doses of 3. Post-therapeutic dosimetry was performed. In FTC, 1 out of 4 patients showed disease stabilization, the other patients had progressive disease.

Both of the patients with the oncocytic variant had SD at current follow-up. The patient with a mixed form showed no response to PRRT and remained progressive.

These results are similar to those reported by other groups. V30 Therapiekontrolle einer Radiopeptidtherapie Y bzw.

Aschoff2, H. Bitzer3, M. Klein1, S. Eschmann4, M. Pfannenberg2, R. Ergebnisse: Die konventionelle Diagnostik s.

Baum1, V. Zachert1, R. Wortmann1, M. Hommann2, D. Lu-TATE was predominantly used for small metastases or in patients with impaired renal or hematological function.

For kidney protection, 1. End stage renal insuffiency was not observed in any of the patients with normal kidney function before PRRT.

Objective tumor responses including significant improvement of clinical symptoms were seen in Reimold1, I.

Liepelt2, W. Maetzler2, G. Reischl3, D. Berg2, R. Bei PDD, z. Die FDG-Verteilung 40min p. Die ersten 7 PD Pat. Diese Maske wurde auf alle Patienten und KO angewendet um einen individ.

Cortex, sowie Teile des front.. In einer mult. Einfluss des MMSE partial corr. Teipel2, C. Zach1, H. Hampel2, P. Bartenstein1, K.

Visuo-spatial impairment is of high clinical relevance as it limits the ability of patients to live in the community. Several PET studies investigated the relationship between the regional pattern of cortical metabolism and the profile of cognitive impairment in AD patients.

Patients with predominant language impairment showed left predominant cortical hypometabolism, whereas predominant right hemispheric hypometabolism was associated with impairment of visuoconstructive abilities.

Aim of this study was to examine the cortical functional representation of visuo-spatial deficits in AD-patients correlating FFDG-PET with neuropsychological domains for the assessment of visual-constructional functioning.

Emission scans were aquired 30 min. In contrast, performance in the analytically more complex RO test also included areas along the ventral visual stream involved in object recognition, and right prefrontal lobe areas involved in sustaining attention and working memory.

Thus, the combination of resting state FDG-PET with a detailed analysis of cognitive profiles in AD is a powerful tool to study the cortical representation of specific cognitive domains in the human brain.

Kendziorra1, P. Meyer1, H. Barthel1, S. Hesse1, A. Schildan1, M. Patt1, A. Seese1, G. Becker1, D. Sorger1, H. Wolf2, H. Gertz2, U.

Hegerl2, O. Entsprechende in-vivo-Daten liegen bisher jedoch nicht vor. Mittels Logan-Plot und einer um radioaktiven Zerfall, Plasmaproteinbindung und Metabolite korrigierten individuellen, arteriellen Input-Funktion wurde das Distributionsvolumen DV errechnet.

Brockmann1, A. Zobel2, K. Biermann1, A. Joe1, J. Bucerius1, L. Scheef3, H. Biersack1, W. Maier2, H. Geplant ist, genetische Daten des Patientenkollektivs in die Analyse mit einzubeziehen.

Reimold1, A. Knobel2, M. Rapp2, C. Solbach3, G. Reischl3, A. Batra4, M. Smolka5, A. Zimmer5, H. Machulla3, R. Bares1, A. V37 Effects of behavioral therapy or pharmacotherapy on scaled brain glucose metabolism in subjects with obsessive-compulsive disorder as assessed by brain FDG PET I.

Apostolova1, S. Block1, R. Buchert1, I. Hand2, M. Clausen1, J. Concomitant major depressive disorder MDD was present in 1 subject only. Post-to-pre-treatment change of scaled LMRGlc SLMRGlc was assessed separately in therapy responders and non-responders within the following volumes of interest selected a priori: left and right head of caudate nucleus, and left and right orbitofrontal cortex.

Whether this effect is primarily related to the improvement of OCD symptoms or it is secondary to concomitant improvement of depression symptoms requires further clarification.

As long as this question is open, severity of depression symptoms should be considered an important covariate in the evaluation of the effects of therapy on the glucose metabolism in subjects with OCD, not only in OCD subjects with concomitant MDD but also in subjects who do not meet the criteria for MDD.

Hesse1, K. Stengler2, R. Regenthal3, G. Becker1, M. Patt1, H. Assmann2, H. Roth4, D. Lobsien4, H. Barthel1, W. Heinke5, U. Neurosci Biobehav Rev ; 2 Ichise et al.

Luthardt1, S. Hesse1, O. Ballaschke2, O. Zimmermanns1, N. Brenner2, H. Royer2, K. Servan2, T. Fischer1, M. Dietlein1, M.

Matzkies3, J. Hescheler3, H. Schicha1, K. Die undifferenzierten Zellen wurden 10 Tage nach Einbringen der Zellen auf die Feederzellen durch Ausschneiden geerntet.

Fischer1, W. Eschner1, B. Zimmermanns1, H. In Vorarbeiten konnte gezeigt werden, dass in Kombination mit Auger-Elektronen emittierenden Radionukliden die markierte Verbindung ein hohes Potenzial zur nebenwirkungsarmen Behandlung ER-positiver Tumoren und insbesondere ihrer Metastasen bietet.

Die mikrodosimetrischen Berechnungen wurden mit Hilfe der von Goddu et al. Nerlich1, R. Lorenz1, V. Meineke2, C. Reiners1, H. Ein eindeutiger Zusammenhang zwischen der Dosis bzw.

Um den Zusammenhang zwischen Dosis bzw. PNAS Rad Res. Seidl1, M. Port2, A. Morgenstern3, M.

Schwaiger1, R. Senekowitsch-Schmidtke1, M. Je ca. Insgesamt 8 Gene waren durchweg hoch- und 12 Gene durchweg herunterreguliert.

Sudbrock1, F. Boldt1, C. Kobe1, H. Insbesondere verdienen PET Untersuchungen mit F besondere Beachtung: Handelt es sich um einen Dauerarbeitsplatz ohne bauliche Abschirmung, so ist die Einhaltung eines Abstands zum Patienten von mindestens sechs bis sieben Metern zum Patienten zu empfehlen.

Benatar NA et al. Greaves CD et al. Empfehlung der Strahlenschutzkommission Barth1, H. Wengenmair2, G. Leissner3, J.

Scuik4, T. Nikula5, O. Rimpler1, S. Senftleben2, I. Barth1, R. Wortmann2, R. Eckardt1, G. Lottes1, O. In einem Beispiel in o.

Truong1, K. Zaplatnikov1, C. Happel1, M. Middendorp1, W. Plastowez1, I. Selkinski1, B. Sauter1, W. Kranert1, J. Diener1, F. Flow - min. Kurve - min.

Die statistische Auswertung erfolgte mittels Spearman-Korrelation. Groth1, S. Dunkelmann1, B. Rohde1, A. Hauschild1, C. Infolge dessen bleibt der Tcm-Pertechnetat-Uptake hoch, der IStundenUptake ist dagegen niedrig bis fehlend.

Nativ besteht keine TSH-Suppression. V50 Radioiodtherapie der funktionellen Autonomie: Welche Zieldosis ist erforderlich? Dittmann1, S.

Rieger1, S. Eschmann1, J. Die weltweit angewendeten Konzepte zur Therapieplanung sind ebenso wie auch die angestrebten Zieldosen unterschiedlich.

Ziel dieser retrospektiven Untersuchung war die Korrelation zwischen erreichter Herddosis und Therapieerfolg sowie die Analyse weiterer prognostisch relevanter Faktoren.

Bachmann1, M. Schmidt1, C. Eine radiogene immunogene Hyperthyreose bzw. Immunhyperthyreose M. Kobe1, I. Weber1, W. Eschner1, F.

Sudbrock1, J. Bachmann1, F. Boldt1, I. Rahlff1, M. Schmidt1, M. Die im Radioiodtest berechnete Zieldosis betrug Gy.

Die thyreostatische Medikation wurde retrospektiv mit dem Therapieergebnis verglichen. V53 M. Hautzel1, K. Kley1, A. Heinzel1, R. Grandt1, A.

Bachofner1, H. Basedow Pat. Die persistierende Hyperthyreose der Non-Responder wurde bei 22 Pat. Basedow Strumen Verkleinerungen zu erreichen, die denen bei M.

Rahlff1, C. Kobe1, W. Boldt1, M. Basedow eine Halbwertszeit von 4,2 d angegeben. Eine individuelle Dosimetrie ist in Deutschland auch gesetzlich vorgeschrieben 1.

Richtlinie nach der StrlSchV. Dunkelmann1, H. Kurth1, P. Groth1, C. Basedow wurde der diagnostische IUptake an einer Sonde nach 4, 6, 8, 10, 22, 24, 26, 32, 46, und 48 Std.

Uptake, der Zeitpunkt des max. Uptakes und die eff. Halbwertszeit HWZ von Radioiod berechnet. Hierzu wurde ein einfaches Zwei-Kompartimentmodell verwendet, welches die intrathyroidale Radioiodkinetik mittels zweier Exponential-Funktionen sehr exakt beschreibt.

Der mittlere max. Die diagnostische eff. Das mittlere Produkt aus kumulativen max. Bei einer VDZ von 2,4 Std.

Manook1, G. Henriksen1, S. Platzer2, A. Weber1, B. Yousefi1, M. Settles3, M. Schwaiger1, H. Wester1, A. Nach i. Buchholz1, B. Alessandri2, M.

Behzad2, H. Baechli3, A. Heimann2, O. Kempski2, M. In Grp. Bei den Paraffintieren ergab sich im Vergleich ipsi- zu kontralateral kein signifikanter Unterschied im Glukosemetabolismus.

Nikolaus1, M. Beu1, R. Larisch2, A. Wirrwar1, H. Dabei entsprachen x und y den freien bzw. BP betrug 2,6. Beu1, C. Antke1, K. Der beobachtete Deckeneffekt wurde zuvor beschrieben 1 und ist u.

Egberts2, R. Buchert3, K. Peldschuss4, H. Kalthoff2, E. Henze1, W. FCholin zeigte dagegen bei allen Zellreihen so gut wie keine Verstoffwechselung.

In unserem Modell nehmen wir an, dass auch hier ein hoher Uptake zu verzeichnen ist aufgrund einer Vielzahl von TK1.

Reuter2, G. Gabriels3, O. Schober1, E. Schlatter2, M. Wirrwar1, D. Buchholz1, O. Gottschalk2, B.

Ostendorf3, F. Schwaiger2, S. Schramm4, H. Michaelis5, M. Sie wurden, bevor sie die Studien begannen, mittels eines makroskopischen Scores eingestuft.

Nach Injektion von Hermann1, M. Kuhlmann1, A. Faust1, K. Kopka1, M. Aufgrund der unterschiedlichen Halbwertzeiten der verwendeten Isotope lassen sich die beiden Tracerinformationen aus dem Listmode-Datensatz separieren.

Herth1, F. Debus2, M. Piel1, M. Palner3, P. Riss1, G. Knudsen3, H. A radioligand competition binding assay was carried out with GF cells, a clonal cell line expressing high amounts of the 5-HT2A receptor, in test tubes containing Faltanserin and seven different concentrations of test compound in a total of 1 mL assay buffer.

Ketanserin was used to determine non-specific binding. To optimize radiochemical yields of the ligand, different reaction parameters were systematically examined.

First autoradiographic and PET images showed excellent and specific binding. Deuther-Conrad1, F. Wegner2, M. Scheunemann1, S. Diekers3, P.

Brust1, A. Besides insomnia, impaired GABAergic neurotransmission has been implicated in various neuropsychiatric diseases.

The radiosynthesis of selected compounds was achieved by n. F nucleophilic substitution. In vitro autoradiography of the F labelled pyrazolopyrimidines was performed on rat and pig brain slices in comparison to Hflunitrazepam.

The in vivo properties of two F labelled derivatives were investigated in NMRI mice by analysing brain uptake, organ distribution, ex vivo autoradiography, and metabolic stability.

The autoradiography of the Flabelled compounds resembles the benzodiazepine binding in rat and porcine brain in vitro. However, the intravenous application of the radiotracers revealed a significant biotransformation and the presence of radiometabolites in the mice brain.

However, the in vivo applicability of the Flabelled indiplon derivatives suffers from an extensive metabolism.

The future work will focus on structural modifications expected to improve the in vivo properties of indiplon derived radiotracers.

Prante1, R. Tietze1, C. Hocke1, S. Gmeiner2, T. We here present the discovery of a promising inverse agonist D4R ligand for PET derived from these lead compounds.

Mitogenesis experiments were performed with a CHOA cell line using quinpirole treatment as a reference. Sprague-Dawley rats were used for biodistributional studies.

LogP was 2. In-vitro rat brain autoradiography demonstrated specific binding in the gyrus dentate of the hippocampus, hypothalamus, medial habenular nucleus, central medial thalamic nucleus, septum and cortex, that was inhibited by FAUC and eticlopride.

Biodistributional studies showed highest uptake in the liver 4. Regional brain uptake was 0. Ex-vivo autoradiography exellently confirmed the in-vitro binding pattern.

Hummerich1, P. Schloss1, F. We were interested in the effect of conformationally restricted N-substituents onto DAT selectivity, affinity and pharmacokinetic properties.

Methods: - -Anhydroecgonin methyl ester was prepared from commercially available cocaine hydrochloride[4]. Addition of an appropriate Grignard reagent[5] and subsequent N-demethylation afforded four p-substituted phenyltropanes a-d.

Results: A promising set of novel tropane-derivatives table 1 has been prepared along with some established selective DAT-radioligands as references.

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